|
KMID : 0613820110210111652
|
|
Journal of Life Science
2011 Volume.21 No. 11 p.1652 ~ p.1657
|
|
|
Characteristics of Hematopoitic Growth Factor, G-CSF and Its Clinical Vision
|
|
Park Jeong-Hae
Park Jung-Ae
Kang Seok-Woo
Goo Tae-Won
Chung Kyung-Tae
|
|
|
Abstract
|
|
|
|
The production of blood cells is regulated by more than 20 different growth factors, called hematopoitic growth factors. These factors have been produced in prokaryotic and mammalian systems for their clinical use. Glranulocyte-Colony Stimulating Factor (G-CSF) is an important therapeutic factor for cancer patients as well as patients with congenital conditions. These patients do not have enough neutrophils and have a high risk of infection. Two groups of recombinant G-CSF have been used to specially treat cancer patients after chemotherapy because chemotherapy induces neutropenia, a major side effect of chemotherapy drugs. Here, structural and biological characteristics of G-CSF are presented. In addition, the relationship between chemotherapy and neutropenia, which is a severe reduction of neutrophils in the blood, and clinical application of G-CSF is discussed. Recombinant G-CSFs are grouped in two forms. Non-glycosylated G-CSF, filgrastim, is produced in Escherichia coli and glycosylated G-CSF, lenograstim, is produced in Chinese hamster ovary cells. Differences in structure and biological activity are compared and challenges for biosimilar production are also highlighted.
|
|
|
KEYWORD
|
|
|
G-CSF, chemotherapy, filgrastim, lenograstim, biosimilar
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|